Gamma-Glutamyltransferase, Atherosclerosis, and Cardiovascular Disease
نویسندگان
چکیده
منابع مشابه
Gamma-glutamyltransferase, atherosclerosis, and cardiovascular disease: triggering oxidative stress within the plaque.
The serum determination of gamma-glutamyltransferase ( -GT) activity is a low-cost, highly sensitive and accurate, and frequently used laboratory test. Although it is considered to be an index of hepatobiliary dysfunction and alcohol abuse,1 recent epidemiology and pathology studies have suggested its independent role in the pathogenesis and clinical evolution of cardiovascular diseases brought...
متن کاملGamma-glutamyltransferase as a cardiovascular risk factor.
The association of a novel factor with clinical vascular disease must meet the same high standard met by ‘traditional’ risk factors. Serum gamma-glutamyltransferase (GGT) activity is a low-cost, highly sensitive laboratory test: though it is currently considered as an index of hepatobiliary dysfunction and alcohol abuse, pathology studies from our group since 1998 have indicated its possible ro...
متن کاملThe Potential Roles of Gamma-Glutamyltransferase Activity in the Pro- gression of Atherosclerosis and Cardiovascular Diseases
The oxidation of low density lipoproteins (LDL) is regarded as a critical factor in the pathogenesis of atherosclerosis, especially the initial steps of the disease. In addition, other oxidative events have been shown to participate in the progression of atherosclerosis and precipitation of cardiovascular events, through modulation of important components of lesions of the vessel wall (smooth m...
متن کاملGenetically elevated gamma-glutamyltransferase and Alzheimer's disease
Observational epidemiological evidence supports a linear and independent association between serum gamma-glutamyltransferase (GGT) concentrations and the risk of Alzheimer's disease (AD). However, the causality of this association has not been previously investigated. We sought to assess the causal nature of this association using a Mendelian randomization (MR) approach. Using inverse-variance ...
متن کاملGamma-glutamyltransferase, cardiovascular disease and mortality in individuals with diabetes mellitus.
BACKGROUND Increased plasma activity of gamma-glutamyltransferase (GGT) is associated with cardiovascular diseases (CVD) and mortality in the general population. We investigated the association between GGT, CVD and mortality in individuals with diabetes mellitus. METHODS Data used were from 1280 participants, aged 35-70 years, with a confirmed diagnosis of diabetes mellitus in the European Pr...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.105.571919